Decrease of kappa-opioid receptor mRNA level in ventral tegmental area of male mice after repeated experience of aggression.
نویسندگان
چکیده
Brain opioid systems have been implicated in the regulation of social interaction, including agonistic behaviour. kappa-Opioid receptor B and C mRNA levels were decreased in the ventral tegmental area but not in the nucleus accumbens in male mice with repeated experience of social victories (winners), but not in mice after social defeats (losers) after 10 but not 20 days of confrontations. mu-Opioid receptor mRNA levels were not changed.
منابع مشابه
Molecular Implications of Repeated Aggression: Th, Dat1, Snca and Bdnf Gene Expression in the VTA of Victorious Male Mice
BACKGROUND It is generally recognized that recurrent aggression can be the result of various psychiatric disorders. The aim of our study was to analyze the mRNA levels, in the ventral tegmental area (VTA) of the midbrain, of the genes that may possibly be associated with aggression consistently shown by male mice in special experimental settings. METHODOLOGY/PRINCIPAL FINDINGS The genes were ...
متن کاملMolecular implications of prolonged aggression experience : Th , Dat 1 , Snca and Bdnf gene expression in the ventral tegmental area of the victorious male mice
Th, Dat1, Snca and Bdnf were the genes whose mRNA levels in the ventral tegmental area of the midbrain were measured in male mice that were victorious in 20 daily agonistic interactions and in a group of such victorious mice that had later not been allowed to fight for 14 days. This experiment demonstrated increased Th, Dat1 and Snca but not Bdnf mRNA levels in the former group as compared to t...
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BACKGROUND Morphine induces adaptive changes in gene expression throughout the reward circuitry of the brain. Here, we investigated the acute and chronic effects of morphine on mRNA levels of κ-opioid receptor in the rat mesocorticolimbic system. METHODS Three groups of rats received ip injection of saline, acute morphine (8.0 mg/kg) and repeated morphine (8.0 mg/kg, once daily for 5 consecut...
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ورودعنوان ژورنال:
- Brain research. Molecular brain research
دوره 135 1-2 شماره
صفحات -
تاریخ انتشار 2005